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Dextromethorph
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- Buy it nowDextromethorphan : Pharmacology, Clinical Uses and Health Effects, Hardcover ...
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Located in: Castle Donington, United Kingdom
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eBay item number:196206514945
Item specifics
- Condition
- Book Title
- Dextromethorphan : Pharmacology, Clinical Uses and Health Effects
- ISBN
- 9781634840163
- Publication Year
- 2016
- Type
- Textbook
- Format
- Hardcover
- Language
- English
- Publication Name
- Dextromethorphan: Pharmacology, Clinical Uses & Health Effects
- Item Height
- 260mm
- Publisher
- NOVA Science Publishers INC International Concepts
- Item Width
- 180mm
- Subject
- Medicine
- Item Weight
- 538g
- Number of Pages
- 216 Pages
About this product
Product Information
Dextromethorphan (DM) is an over-the-counter antitussive drug that is also used as one of the active ingredients in many cold and cough medicines. In recent years, DM has also been used in other medicines, ranging from pain relief (as either the primary analgesic or an opioid potentiater) over psychological applications to the treatment of addiction. Pharmacodynamics of DM have been gradually discovered with the elucidation of the following properties, including uncompetitive NMDA receptor antagonist, sigma1 and sigma2 sigma receptor agonists, alpha3ss4-nACh receptor antagonist, and others. DM is transformed to its primary and active metabolite dextrorphan predominantly via the metabolic enzyme cytochrome P450 (CYP) 2D6. Hence, DM is the first-choice substrate for CYP2D6 phenotyping because it is relatively safe and possesses many favorable pharmacokinetic characteristics for a marker substrate. This book aims to meet the needs of basic molecular biochemists, pharmacologists, pharmacists, medical students, clinical practitioners and scientists, as well as broad readers who wish to understand the pharmacology of DM and its clinical uses. The contributing authors are basic scientists, pharmacologists, pharmacists and on-service physicians in neuro-psychiatric, anesthesiologic and hepatologic fields from the Czech Republic, Austria, the United States, and China. As a collection of masterpieces by well-known experts, this book presents current research in the study of DM, focusing on its pharmacology, clinical uses and health effects. Topics discussed in this compilation include the new pharmacological application of DM; pharmacogenetics of DM; pharmacodynamics and toxicological profiles of DM; long cutaneous block by lidocaine and DM; toxic and beneficial effects of DM on the central nervous system; pharmacokinetics of DM and drug interactions; DM as a probe drug for CYP2D6 and CYP3A4 phynotyping; evaluation of CYP2D6 in DM-herb interactions; and clinical uses and health effects of DM.
Product Identifiers
Publisher
NOVA Science Publishers INC International Concepts
ISBN-13
9781634840163
eBay Product ID (ePID)
221291797
Product Key Features
Publication Name
Dextromethorphan: Pharmacology, Clinical Uses & Health Effects
Format
Hardcover
Language
English
Subject
Medicine
Publication Year
2016
Type
Textbook
Number of Pages
216 Pages
Dimensions
Item Height
260mm
Item Width
180mm
Item Weight
538g
Additional Product Features
Country/Region of Manufacture
United States
Editor
Dr Xin Wang
Item description from the seller
Business seller information
Far Corner Europe Limited
Barbara Blake
19-20 Bourne Court
Southend Road
Woodford Green
Essex
IG8 8HD
United Kingdom
Value added tax number:
- GB 307932304
Trade registration number:
- 10691061
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eBay item number:196206514945
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