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Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificia

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Item specifics

Condition
New: A new, unread, unused book in perfect condition with no missing or damaged pages. See the ...
ISBN-13
9780470686683
Book Title
Chemistry and Biochemistry of Oxygen Therapeutics
ISBN
9780470686683
Subject Area
Physical Therapy
Publication Name
Chemistry and Biochemistry of Oxygen Therapeutics: from Transfusion to Artificial Blood
Publisher
John Wiley & Sons INC International Concepts
Subject
Chemistry
Publication Year
2011
Type
Textbook
Format
Hardcover
Language
English
Item Height
252mm
Author
Andrea Mozzarelli, Stefano Bettati
Item Width
171mm
Item Weight
958g
Number of Pages
466 Pages

About this product

Product Information

Human blood performs many important functions including defence against disease and transport of biomolecules, but perhaps the most important is to carry oxygen ? the fundamental biochemical fuel - and other blood gases around the cardiovascular system. Traditional therapies for the impairment of this function, or the rapid replacement of lost blood, have centred around blood transfusions. However scientists are developing chemicals (oxygen therapeutics, or ?blood substitutes?) which have the same oxygen-carrying capability as blood and can be used as replacements for blood transfusion or to treat diseases where oxygen transport is impaired. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood links the underlying biochemical principles of the field with chemical and biotechnological innovations and pre-clinical development. The first part of the book deals with the chemistry, biochemistry, physiology and toxicity of oxygen, including chapters on hemoglobin reactivity and regulation; the major cellular and physiological control mechanisms of blood flow and oxygen delivery; hemoglobin and myoglobin; nitric oxide and oxygen; and the role of reactive oxygen and nitrogen species in ischemia/reperfusion Injury. The book then discusses medical needs for oxygen supply, including acute traumatic hemorrhage and anemia; diagnosis and treatment of haemorrhages in non-surgical patients; management of perioperative bleeding; oxygenation in the preterm neonate; ischemia normobaric and hyperbaric oxygen therapy for ischemic stroke and other neurological conditions; and transfusion therapy in ? thalassemia and sickle cell disease Finally ?old?and new strategies for oxygen supply are described. These include the political, administrative and logistic issues surrounding transfusion; conscientious objection in patient blood management; causes and consequences of red cell incompatibility; biochemistry of red blood cell storage; proteomic investigations on stored red blood cells; red blood cells from stem cells; the universal red blood cell; allosteric effectors of hemoglobin; hemoglobin-based oxygen carriers; oxygen delivery by natural and artificial oxygen carriers; cross-linked and polymerized hemoglobins as potential blood substitutes; design of novel pegylated hemoglobins as oxygen carrying plasma expanders; hb octamers by introduction of surface cysteines; hemoglobin-vesicles as a cellular type hemoglobin-based oxygen carrier; animal models and oxidative biomarkers to evaluate pre-clinical safety of extracellular hemoglobins; and academia ? industry collaboration in blood substitute development. Chemistry and Biochemistry of Oxygen Therapeutics: From Transfusion to Artificial Blood is an essential reference for clinicians, haematologists, medicinal chemists, biochemists, molecular biologists, biotechnologists and blood substitute researchers.

Product Identifiers

Publisher
John Wiley & Sons INC International Concepts
ISBN-13
9780470686683
eBay Product ID (ePID)
111743182

Product Key Features

Subject Area
Physical Therapy
Author
Andrea Mozzarelli, Stefano Bettati
Publication Name
Chemistry and Biochemistry of Oxygen Therapeutics: from Transfusion to Artificial Blood
Format
Hardcover
Language
English
Subject
Chemistry
Publication Year
2011
Type
Textbook
Number of Pages
466 Pages

Dimensions

Item Height
252mm
Item Width
171mm
Item Weight
958g

Additional Product Features

Country/Region of Manufacture
United States
Editor
Stefano Bettati, Andrea Mozzarelli

Item description from the seller

Business seller information

ABC Books Ltd
Unit 2D
Gatwick Gate Industrial Estate
Crawley, Lowfield Heath
London
RH11 0TG
United Kingdom
Value added tax number:
  • GB 324767388
Trade registration number:
  • 05034144
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