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Transporters as Targets for Drugs - 9783642099694
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Item specifics
- Condition
- Book Title
- Transporters as Targets for Drugs
- ISBN
- 9783642099694
- Publication Year
- 2010
- Type
- Textbook
- Format
- Paperback
- Language
- English
- Publication Name
- Transporters As Targets for Drugs
- Item Height
- 235mm
- Publisher
- Springer-Verlag Berlin AND Heidelberg Gmbh & Co. KG
- Item Width
- 155mm
- Subject
- Medicine, Chemistry, Biology, Psychiatry
- Item Weight
- 460g
- Number of Pages
- 254 Pages
About this product
Product Information
Transporters are proteins that span the plasma membrane and regulate the traf?c of small molecules in and out of the cell. They play a particularly important role in chemical signalling between neurons in the CNS, where they act to control the concentration of neurotransmitters in the synapse. In most systems the termination of chemical transmission is achieved by rapid uptake of the transmitter molecule from the synapse by transporters located on the synaptic terminal or surrounding glial cells. Another key role for transporters is in excluding undesirable xenobiotics from the cell, whilst allowing key molecules required for the cell life cycle to enter. It is incre- ingly recognised that these ef?ux or uptake transporters respectively, play an important role in the disposition of many marketed drugs, and whilst the ?eld of drug transport is yet to attain the level of maturity of drug metabolism,itiscertaintobeofincreasingimportance infuturedrugdisc- ery programmes. 2 Transporter Classification Transporters can be classed into two main families; the ATP binding c- sette (ABC) family, and the solute carrier (SLC) family. The SLC family is a very broad categorisation which encompasses, amongst others, three - portant families of transporters for organic molecules; the major facilitator superfamily (MFS) and two neurotransmitter transporter families, the neu- transmitter; sodium symporter (NSS, or SLC6) and the dicarboxylate/amino + + acid:cation (Na or H ) symporter (DAACS, or SLC1) family.
Product Identifiers
Publisher
Springer-Verlag Berlin AND Heidelberg Gmbh & Co. KG
ISBN-13
9783642099694
eBay Product ID (ePID)
109230164
Product Key Features
Publication Name
Transporters As Targets for Drugs
Format
Paperback
Language
English
Subject
Medicine, Chemistry, Biology, Psychiatry
Publication Year
2010
Type
Textbook
Number of Pages
254 Pages
Dimensions
Item Height
235mm
Item Width
155mm
Volume
4
Item Weight
460g
Additional Product Features
Series Title
Topics in Medicinal Chemistry
Editor
Matilda Bingham, Susan Napier
Country/Region of Manufacture
Germany
Item description from the seller
Business seller information
BOOKS ETC LIMITED
Andy Smith
Books Etc, Unit 4
Eastern Road
Aldershot
Hampshire
GU12 4YD
United Kingdom
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eBay item number:314630358841
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